E-Posters - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.02 - GENETICS, OMICS AND BIOMARKERS P2587 - ESOC25-1868 DYNAMIC GENE EXPRESSION IN EXPERIMENTAL SUBARACHNOID HEMORRHAGE Emelie Fungbrant 1 , Jesper Bmers 2 , Anja Holm Nordvang 3 , Kristian Agmund Haanes 4 , Lars Edvinsson 5 , Tiit Mathiesen 6 1 Department of Neurosurgery, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark, Department of Clinical Experimental Research, Glostrup Research Institute, Copenhagen University Hospital, Rigshospitalet Glostrup, 2600 Glostrup, Denmark., Copenhagen, Denmark, 2 Department of Clinical Experimental Research, Glostrup Research Institute, Copenhagen University Hospital, Rigshospitalet Glostrup, 2600 Glostrup, Denmark., copenhagen, Denmark, 3 Department of Clinical Experimental Research, Glostrup Research Institute, Copenhagen University Hospital, Rigshospitalet Glostrup, 2600 Glostrup, Denmark., Copenhagen, Denmark, 4 Department of Clinical Experimental Research, Glostrup Research Institute, Copenhagen University Hospital, Rigshospitalet Glostrup, 2600 Glostrup, Denmark, Department of Biology, Section of Cell Biology and Physiology, University of Copenhagen, Denmark, Copenhagen, Denmark, 5 Division of Experimental Vascular Research, Department of Clinical Sciences, Lund University Hospital, Lund, Sweden., Copenhagen, Denmark, 6 Department of Neurosurgery, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark, Copenhagen, Denmark Background and Aims: Delayed cerebral ischemia (DCI) following subarachnoid hemorrhage (SAH) leads to significant morbidity, with few patients returning to full-time employment

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162 In vitro cell culture and in vivo rat model study showed that melatonin delayed the progression of IL-1-induced IVDD and related LBP via inhibiting the IL-1/NF-B-NLRP3 inflammasome activation positive feedback loop, and downregulating mitochondrial reactive oxygen species (mtROS) production, suggesting melatonin might be a considerable potential clinical agent for IVDD