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To determine the role of GpoA during pneumococcal infection, we constructed the gpoA mutant in the capsulated D39 strain (serotype 2), which is virulent in BALB/c mice using intranasal inoculation [38], and its corresponding revertant strain ( wt gpoA + )

Rodents consuming prebiotics like bovine milk oligosaccharides, oligofructose-enriched inulin, spirulina platensis, and a combination of Fructooligosaccharide/Galactooligosaccharide have exhibited decreased plasma levels of lipopolysaccharides, lower serum concentrations of pro-inflammatory cytokines, diminished intestinal inflammation, and enhanced tight-junction integrity [93,94,95,96,97]

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