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Therefore, it will be interesting in future studies to explore if different blood levels of these cofactors can be linked to the severity of GLP-1 resistance in individuals with hypomorphic T2D-risk alleles [53]

This is a medical emergency and requires urgent treatment

The excitement around peptides for bone healing is warranted by the preclinical evidence, but several important limitations must be acknowledged

However, it is important to emphasise that GLP-1 agonists are not specifically licensed for treating leptin resistance as a distinct condition

Important safety considerations include a boxed warning for medullary thyroid carcinoma risk (contraindicated in patients with MEN2 or family history of MTC), pancreatitis risk, gallbladder disease, and potential for dehydration