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Memory and learning depend on healthy synapses, and proteins that maintain those synapses tend to decline with age

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These concerns are worsened when these medicines can be utilized extensively and inappropriately, hastening the evolution of drug-resistant mutations over time (Smith et al., 2019)

Safety considerations Available evidence suggests that combined therapy with SGLT2 inhibitors and GLP-1 receptor agonists is generally well tolerated, with safety profiles largely consistent with those of each class individually [24, 40,41,42,43]

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