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Decreased urine output or difficulty urinating, potentially signaling dehydration or kidney dysfunction Dark-colored or concentrated urine , which typically indicates dehydration, especially following gastrointestinal side effects Painful urination, urgency, or burning sensation , suggesting a possible urinary tract infection that may require antibiotics Blood in the urine (hematuria), which requires prompt evaluation regardless of other symptoms Foamy or frothy urine that persists, potentially indicating proteinuria or kidney disease Dehydration is a particular concern with semaglutide due to its gastrointestinal side effects

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When semaglutide activates GLP-1 receptors in these brain regions, it enhances satiety signals and reduces hunger perception

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