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Its longer half-life (approximately 2 hours vs
The pretreatment with Ab reduced the systemic levels of inflammatory cytokines (TNF-, IL-1), increased the antioxidant response in several organs and tissues (GSH and TEAC) with concomitant inhibition of oxidative damage (lipid peroxidation in serum, peritoneal cavity, heart and liver) of septic mice
However, in our experimental model with BRIN-BD11 cells, 18 h exposure to 50 nM Ex-4 did not induce significant changes in cell numbers (Fig
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To add to this, VRK2 overexpression significantly attenuated TBHP-mediated cell death, which could be efficiently reversed by BFA treatment (Fig
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