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For example, many supplements contain caffeine, which acts as a diuretic and eliminates fluid from your body, per the NIH

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Produced in the hypothalamus, the brains control center for many bodily functions, it causes the pituitary gland to release growth hormone.4 5 Growth hormone, in turn, acts on almost every organ and tissue in two aspects: Physical growth Growth hormone signals the cells in your cartilage and bones to ramp up their replication, especially during adolescence

It influences inflammation and affects how efficiently you use energy