According to the FDA's official guidance (updated April 2026 at fda.gov), the semaglutide injection shortage was resolved on February 21, 2025, and the transitional exemption windows for compounders operating under the shortage exemption subsequently ended - for 503A pharmacies by April 22, 2025, and for 503B outsourcing facilities by May 22, 2025
You can eat before taking your first semaglutide GLP-1 injection, and in many cases, it is recommended
If you experience persistent nausea, vomiting, or severe bloating after starting semaglutideespecially in the first 4 weekseliminating caffeine for 710 days serves as a diagnostic tool to isolate medication effects
in contrast, oral DPP-IV inhibitors (that produce less GLP-1 mediated stimulation) have been shown to cause significant weight loss
5 Cardiovascular Outcomes Cardiovascular outcomes trials with canagliflozin (Canagliflozin Cardiovascular Assessment Study