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In both, fat and liver, GH stimulates the synthesis of p85 subunit of PI3K [166] leading to the suppression of p110 subunit activity and, thus, antagonising insulins actions [167]

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Gene expression (4,000+ genes) A 2018 review of Broad Institute Connectivity Map data reported that GHK modulates the expression of more than 4,000 human genes, spanning collagen synthesis, DNA repair, antioxidant defense, and anti-inflammatory pathways (Pickart & Margolina, International Journal of Molecular Sciences, 2018)

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ECG, epicatechin gallate