Screening of mutants with improved glutathione content and concentration A mutant library was constructed using UV exposure, following the method described by (Lee et al., 2023)
The results exhibited a significant reduction in the proliferation activity of MCF-7 cells treated with CuNPs, recorded IC 50 value of 57.2 3.1 g/ml, while nano-chrysin IC 50 was 125.4 6.2 g/ml (IC 50 is the concentration that reduced the initial count of viable MCF-7 cell line by 50% compared to untreated control cells)
Under stress conditions, astrocytes may release toxic factors that amplify neuronal damage [134]
Interventions to improve patients prognostic understanding while providing adequate psychosocial support are warranted
For example, in prostate cancer cells, it elevates the expression of the pro-apoptotic protein Par-4 and activates downstream caspases, while in cervical cancer cells, it reinstates p53 expression, thereby stimulating Bax and other pro-apoptotic members of the Bcl-2 family to induce cell death [109]