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Mechanistically, melatonin acted independently of canonical melatonin receptors and instead reprogrammed ILC2 metabolism toward pentose phosphate pathway activity, enhancing NADPH generation and NRF2-dependent glutathione accumulation

The peptide is intended solely for basic research and the structural characterization of metal-binding peptide complexes

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Thus, it is the tight coupling of the HMP shunt and glutathione metabolism that is responsible for protecting intracellular proteins from oxidative assault

Sanchez-Gurmaches, J