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Plasma AMG 133 exposure as assessed by maximum observed concentration ( C max ) and area under the concentrationtime curve (AUC) from time 0 to the time of the last measured concentration (AUC last ) increases with increasing dose

Dietary Changes: Protein First: You must prioritize protein intake to protect your muscle mass as you lose weight

This accumulation pattern is why many patients experience stronger appetite suppression and weight loss effects after several weeks of consistent dosing rather than immediately after the first injection

DM patients treated with GLP-1 RA and/or SGLT-2i as part of their therapy