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Nuclear translocation of G and arrestins in the tolerance conditions of D2-like receptors.The cells were labeled with arrestin2/3 antibodies (1:1000), followed by Alexa 555-conjugated secondary antibodies (1:500)

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Contributing to free intracellular calcium levels is the release of calcium stored in the endoplasmic reticulum (ER) via the activation of calcium-activated calcium release channels, specifically the type 2 ryanodine receptor (RYR2)