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These doses help the body gradually adapt to medication and reduce early side effects

A founder and past chairman of the American Board of Obesity Medicine and a past president of the Obesity Society, Dr

Hooper L, Martin N, Abdelhamid A, Davey Smith G

Heres a look at common biologic classes and their half-lives: o Humira (adalimumab): 68 weeks o Enbrel (etanercept): 2 weeks o Remicade (infliximab): 46 weeks o Cosentyx (secukinumab): 4 weeks o Stelara (ustekinumab): 12 weeks o Tremfya (guselkumab): 8 weeks o Xeljanz (tofacitinib): 12 weeks o Rinvoq (upadacitinib): 12 weeks A common approach physicians might take to accommodate for the variation in drug half-lives is to stop one full dosing interval before major implant surgery for each biologic, with consideration for a longer hold where theres a high risk for infection or poor wound healing

10.1038/s41556-021-00818-3 201 ZhangJ.WangX.GuanB.WangX.AnX.WangT.et al (2023b)