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10.1016/j.fertnstert.2020.06.037 59 SolekP.MytychJ.Tabcka-onczyskaA.KoziorowskiM

4.4 SURPASS-4 trial comparison of tirzepatide and insulin glargine The SURPASS-4 trial included 1,995 patients with type 2 diabetes and compared tirzepatide (5 mg, 10 mg, 15 mg) with insulin glargine over 52 weeks, with the primary endpoint being the change in HbA1c (Heerspink et al., 2022)

Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

A study in Cell Metabolism demonstrated that GIP receptor activation in adipose tissue can promote fat oxidation under certain conditions (Samms et al., 2020) Synergy with GLP-1 When GIP and GLP-1 receptors are activated together, the combined effect on appetite suppression and insulin sensitivity exceeds what either achieves alone

It promotes the formation of new collagen and elastin while regulating enzymes (MMPs) that break down excess or poorly formed scar tissue, replacing it with stronger, healthier structures