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If there is concern about TMAO risk, clinicians can discuss the limited evidence, consider monitoring and prefer conservative dosing

Additionally, that study was done in a private practice setting and published in an alternative medicine journal, raising questions about oversight and objectivity

Department of Health and Human Services, ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/

N,Nbis-(2-mercaptoethyl) isophthalamide (NBMI), a lipophilic thiol-based chelator with selective affinity for ferrous iron, has demonstrated superior brain chelation efficacy in a mouse model of brain iron overload, making it a promising candidate for IN formulations if its solubility limitations can be addressed (Cheng et al., 2022)

To that point, the FDA has recently identified a few issues in compounded GLP-1s on the market