Glu5 antagonists improve the social and stereotypic behaviors in rodent models of ASD [146]
J Practical Liver Dis
PRODUCT FOCUS: PEPTIDES AND PROTEINS PROCESS FOCUS: FORMULATION/STABILITY WHO SHOULD READ: ANALYTICAL AND FORMULATION DEVELOPMENT, PROCESS DEVELOPMENT, QA/QC AND REGULATORY AFFAIRS KEYWORDS: FORCED DEGRADATION, PROTEIN DEGRADATION, OXIDATION, DISULFIDE SCRAMBLING, DEAMIDATION, AGGREGATION, HYDROLYSIS LEVEL: INTERMEDIATE Advances in analytical chemistry have identified many degradation pathways that can occur in recombinant protein therapeutics over time
155 Furthermore, GDH-derived NADPH is consumed to support the reductive carboxylation of -KG by IDH2, and the compensatory increase in the expression of GDH1 or GDH2 promote the growth of IDH-mutant glioma cells
Sci Rep 14(1):1904 Khalid M, Petroianu G, Adem A (2022) Advanced glycation end products and diabetes mellitus: mechanisms and perspectives