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doi: 10.7324/JABB.2024.142595 85 WangYXuJChenHShuYPengWLaiCet al

Boolean operators and Medical Subject Headings (MeSH) were applied to refine the search strategy

"Centenarians display plasma MOTS-c concentrations significantly higher than age-matched peers, a pattern that closely resembles levels found in individuals decades younger suggesting preserved mitochondrial signaling as a hallmark of exceptional longevity." The connection to cellular senescence deserves further attention here

Together, these interconnected processes highlight the complexity of ferroptosis, which depends on the regulation of iron homeostasis, lipid peroxidation, and oxidative stress, with the NADPH oxidase system playing a key role in amplifying the damage ( Figure 1 )

Current Molecular Medicine