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Consequently, changes in GM and short-chain fatty acids in PCOS patients can trigger the release of brain mediators, such as gastric starvation hormone and PYY, which in turn affect the secretion of sex hormones, the regulation of central neurotransmitters, and downstream neuronal functions as well as immunomodulation ( 3.5.1 Hypothalamic-pituitary-gonadal axis Hypothalamic gonadotropin-releasing hormone (GnRH) neurons secrete GnRH, which regulates the secretion of follicle-stimulating hormone (FSH) and LH from the pituitary gland

Future research should further explore the details of these associated mechanisms to develop more effective prevention and treatment strategies

Most dermatology treatments are designed to reduce pigmentation and improve skin clarity rather than permanently change natural skin color

doi: 10.1111/vco.12086 8 JohannesCMMusserML

It is important to note that peptides often demonstrate pleiotropic effects, influencing multiple physiologic pathways beyond their target tissue