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249,250 Acute systemic injections of the bacterial antigen lipopolysaccharide (LPS) in mice induces diffuse inflammatory changes in the CNS and mimics this sickness behaviour and is often used as a model to study effects of inflammation on CNS functions

It is necessary to continue molecular research on the epithelial barrier in order to develop preventive guidelines for maintaining its tightness, to develop new methods for evaluation of its functionality and therapy in case of diagnosed damage

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JAMA Psychiatry (2017) 74(11):11618