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TXNRDs catalyze the reduction of a wide range of substrates, including thioredoxin and protein disulfide isomerase (PDI) (see Figure 2b )

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The Autism Science Foundation said in its statement that there are four studies suggesting low folate levels in pregnant women could increase the risk of autism, but it said "this science is still in very early stages, and more studies are necessary before a definitive conclusion can be reached."

Most experts recommend limiting use to twelve weeks followed by an equal rest period