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In ALCAR-treated xenografts, we observed a trend toward a reduced microvascular density, as revealed by histology (Additional file 1: Figure S4)

Neuroimaging data have revealed that diabetes patients often present with white matter damage and reduced brain volumes, which may be a consequence of BBB injury [3]

synaptophysin (MO 776) from Leica (Newcastle, UK), insulin (I-2018) from Sigma (Buchs, Switzerland), glucagon from Sigma (Buchs, Switzerland), somatostatin from Dako (Baar, Switzerland), and PP (RP030) from Diagnostic BioSystem (Pleasanton, CA, USA)

Abdelmalek, J