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Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism

26 , S57S67 (2022)

Treatment options, dosing, and eligibility should be discussed with a licensed healthcare professional

In AECs, TLR4/NF-B activation contributes to a pro-ferroptotic intracellular environment by upregulating genes such as NOX1 and NOX4 (promoting ROS production) and ACSL4 (increasing PUFA-containing phospholipid substrates), while suppressing ferroptosis-protective genes like GPX4 through redox imbalance and inflammatory stress (8688)

GSH is required for stable iron delivery by poly(rC)-binding protein 1 (PCBP1) to ferritin and other client proteins 130