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Description

Zepbound is the only one that's FDA-approved for sleep apnea, specifically among people with obesity (defined as a BMI of over 30)

These authors showed that a ligand-free ligand binding domain (LBD) of PPAR is significantly more flexible than the rest of the LBD, indicating that this binding pocket is intrinsically disordered in order to accommodate different ligands (Hamuro et al., 2006)