Ethical approval Ethics approval was not required for this study
Red-flag symptoms to call your clinician about Severe, persistent abdominal pain, especially radiating to the back (pancreatitis evaluation) Right-upper-quadrant pain, fever, jaundice (gallbladder disease) Severe vomiting, inability to tolerate fluids, or severe constipation/bloating (possible ileus or marked delayed emptying) Black stools or blood in stool/vomit (urgent evaluation) Product labels and FDA communications specify stopping the drug and urgent workup for suspected pancreatitis or gallbladder complications
It was proposed that since icodec has a longer fatty diacid side chain compared to semaglutide (20-carbon versus 18-carbon long fatty diacid, respectively), icodec would have a relatively higher affinity for albumin and thus could outcompete semaglutide for the fatty acid binding sites on albumin
Vallerie, Sara N., and Karin E
Monitoring your pet for any signs of adverse reactions, such as vomiting, diarrhea, or excessive salivation, is also important