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Together, these data suggest that Bach1-HO-1 signaling critically regulates oxidative stress-induced ferroptosis

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Its highest expression is on the luminal surface of the proximal tubules in the kidney, whilst the bile ducts, bile canaliculi, and endothelial cells of the nervous system capillaries also have high expression (Shiozawa et al., 1989

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Methylene blue must be avoided by individuals with G6PD Deficiency, taking Serotonergic Drugs (SSRIs, SNRIs, MAOIs), or pregnancy and nursing to avoid complications