The transcription factor NFE2L2 (Nrf2) positively regulates SLC7A11 expression, whereas tumor suppressors such as TP53, BAP1, and BECN1 downregulate SLC7A11 , increasing ferroptosis sensitivity ( 3.1.2 Relationship between lipid metabolism and ferroptosis PUFAs, particularly those containing bis-allylic hydrogen atoms such as arachidonate (AA) and adrenate (AdA), are highly susceptible to oxidation by ROS, making them central to ferroptosis ( Lipoxygenases (LOXs), iron-containing enzymes, play a direct role in inducing ferroptosis by catalyzing the peroxidation of membrane-bound PUFAs
However, despite its efficacy, high dropout rates from the study were seen due to side effects
The next generation PRP includes, PRF AND GFC
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