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doi: 10.1007/s00280-015-2716-9, 23

PMC 10761640

Data from human and animal studies provide strong evidence of neurovascular unit dysfunction with BBB hyperpermeability in association with oxidative stress and neuroinflammation (118), which can increase the susceptibility to neurological disorders such as depression

The parent compound, Nle-AngIV, demonstrated an exceedingly short half-life of less than 2 minutes

GHK-Cu (copper peptide GHK-Cu, or glycyl-L-histidyl-L-lysine:copper(II)) is a naturally occurring tripeptide-copper complex found in human plasma, saliva, and urine