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Nuclear Translocation and Gene Regulation Under metabolic stress conditions, MOTS-c peptide translocates from mitochondria to the nucleus, where it regulates genes containing antioxidant response elements (ARE)

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This can provide staging and prognostic information

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Immediately evaluate patients presenting with pain or tenderness, erythema, or swelling in the genital or perineal area, along with fever or malaise, for necrotizing fasciitis and if suspected, discontinue SYNJARDY or SYNJARDY XR, and promptly institute appropriate medical and/or surgical intervention