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This is the foundational principle of pharmacology, stated by Paracelsus 500 years ago: the dose makes the poison, and by extension, the dose makes the medicine

Conversely, semaglutide, with strong cardiovascular outcomes and weight-loss efficacy, may be better suited for individuals with obesity, T2DM, or high cardiometabolic risk, where it can improve histology and provide extra-hepatic benefits through calorie reduction and glycemic control

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Weber JS, Hodi FS, and Wolchok JD, et al (2017) Safety profile of nivolumab monotherapy: a pooled analysis of patients with advanced melanoma J Clin Oncol 35 (7) 785792 PMID: 28068177 42