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Among them, metabolic modulators, exemplified by metformin, effectively regulate the Treg/Th17 balance of patients with RA through the activation of AMPK and the inhibition of key signaling pathways, such as mTOR, STAT3, and HIF-1, attenuating the inflammatory response and inhibiting osteoclast formation, thereby alleviating disease progression (219)

Diagnosis of MASLD was confirmed through a combination of imaging techniques, including ultrasound, Magnetic Resonance Imaging (MRI), and Fibroscan, which assessed liver fat accumulation and liver stiffness, alongside liver biopsy, which established the presence of liver fat of 5% to indicate steatosis

The development of health and medical research

Shils, M

Group 3: Rats received l-carnitine (200 mg/kg/day, i.p.) for 10 uninterrupted days [28]