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In SURPASS-5, all participants received background treatment with insulin glargine (titrated following a treat-to-target algorithm) metformin

This is why regular medical check-ups with a healthcare provider are so important

However, tesofensine faces significant challenges - cardiovascular side effects (increased heart rate and blood pressure) raised safety concerns, FDA has not approved it despite promising efficacy data, development stalled after Phase 3 trials, currently available only through research chemical suppliers with questionable legality, and the stimulant-like mechanism creates dependency and tolerance risks not seen with GLP-1 agonists

In fact, clinical trials have not shown that these increases lead to heart problems for most people

Prerequisites: Open to Medics & Non-Medics Minimum Requirement : Level 3 beauty qualification