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It has been found that ascorbate (100 M, 60500 mg/kg/day) significantly protects cells/organisms against an increase in 4-HNE and MDA levels under stress conditions, including UV-induced oxidative stress in skin cells [33,34,84] or cornea [116] and the toxic effects of xenobiotics in liver cells [117,118,119,120] and erythrocytes [121], as well as oxidative stress-related myonecrosis [122]