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The precise mechanism underlying ferroptosis is still unknown, but it is known that altered iron metabolism, glutathione (GSH) depletion, GPX4 inactivation, and increased PUFA peroxidation by ROS play key roles in its onset and progression [80, 81]

[DOI] [PMC free article] [PubMed] [Google Scholar] 262.Zhou Y., Liu L., Tao S., Yao Y., Wang Y., Wei Q., Shao A., Deng Y

The continuous production of ONOO could suppress the activity of glutathione reductase by nitration modification, thus collectively reducing detoxification and blocking DNA damage repair

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Multiple level herniations Some individuals have herniations at more than one level