Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels
Collectively these studies suggest that GSH may facilitate cascading events leading to oxidative stress (Bharath et al., 2011)
doi: 10.1007/s10930-009-9208-x 49 GaoMMonianPQuadriNRamasamyRJiangX
When glutathione levels are depleted - as they consistently are in Hashimoto's thyroiditis, Graves' disease, and hypothyroidism - the consequences cascade: oxidative thyroid damage, protein modification, autoantigen formation, immune activation, and progressive thyroid destruction
Simple rule: NAC supports glutathione pathways, glutathione offers direct antioxidant support, milk thistle is herbal liver support, and blends provide a broader formula