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Remarkably, NDI1 expression led to improved glucose tolerance and reduced insulin release during the glucose tolerance test (GTT) (Fig

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Although the observational nature of our study does not allow us to determine whether the lower hyperkalemia rates causally explain this finding, many studies show that hyperkalemia often leads to dose reduction or discontinuation of renin-angiotensin system inhibitor use in clinical practice and that this clinical decision is associated with worse clinical outcomes. The researchers noted the study lacked information on race and ethnicity and the findings may not be generalizable in other regions of the world.