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Ablation of peroxiredoxin 1 and 2 is further associated with increased T helper type 2 (Th2)-mediated cytokine release, airway hyperresponsiveness to methacholine, B-cell activation, and T-cell proliferation (146, 227), suggesting that peroxiredoxins are central to the airway antigenic response

The Gpx family of glutathione peroxidases is an evolutionarily highly conserved group of enzymes containing eight main isoenzymes, among which Glutathione Peroxidase 4(GPx4) utilizes GSH as a cofactor to convert lipid hydroperoxides into nontoxic lipids alcohols and reduce free radical accumulation (36)

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However, the differences in free GSH and GSSG did not affect their relative ratio (Fig