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11,12 The BMJ guideline differs somewhat from other organizations

With these promising results, Amylin, Eli Lilly, and Alkermes, the companies involved with the development of Bydureon, submitted an application (called a New Drug Application or NDA) to the FDA asking for approval to sell the drug in the United States

FDA-approved since 2022 with growing post-marketing experience

Therefore, while elevated total antibodies might reflect a broad immune response, the presence of TRAb indicates a more targeted autoimmune phenomenon rather than a nonspecific antibody surge

This distinction matters enormously when considering whether rotation between them is safe, effective, or even practical