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Research has found that competitive bodybuilders have some of the highest recorded muscle carnosine levels, further supporting the idea that high carnosine levels contribute to bodybuilding success

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Simultaneously, Akt phosphorylates the FOXO family of transcription factors (FOXO1, FOXO3, FOXO4), sequestering them in the cytoplasm and preventing them from transcribing the atrogenes MuRF1 and atrogin-1/MAFbx that drive ubiquitin-proteasome-mediated muscle protein breakdown