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High-calorie meals, overweight/obesity, gastrointestinal postprandial oxidative stress (POS), insulin resistance, hyperglycemia, and pancreatic beta-cell dysfunction are examples of risk factors that can modulate both local and systemic OxS in T2D
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If targets are not achieved, additional RAI should be added at one and then two other mealtimes (basal-bolus) as required, with titration as for the initial RAI [2, 3, 18]
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