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Orforglipron, by contrast, is a small molecule drug and is meant to be taken orally

Because of that, plants developed complexed ROS control system based on enzymes (like glutathione reductase-GR, glutathione S-transferase-GST, glutathione peroxidase-GPX) and scavenging non-enzymatic hydrophilic molecules like ascorbate (AsA) and glutathione (GSH) (Noctor and Foyer, 1998)

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Importantly, protein levels of GCLC followed the trend observed with Nrf2 protein: GCLC levels were elevated by NFT treatment, and anti Nrf2-siRNA largely prevented this increase (Fig

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