95% CI 10.351.4) 10% loss: 65% vs 9% Nearly half lost 15% body weight Improved BP, HbA1c, and lipids Safety GI side effects: 63% vs 35% placebo (mostly mild/moderate) Discontinuations: ~4.5% on semaglutide Safety profile consistent with GLP1 RAs Why It Matters First large East Asian RCT showing potent weight loss with oral semaglutide a needlefree option matching the efficacy of many injectable regimens
Cheong, H., Lindsten, T., Wu, J., Lu, C
Among 710 patients with type 2 diabetes, there were 17 cases of NAION in patients prescribed semaglutide (the scientific name of both drugs)
On the third day, the brain slices are washed three times in TNT buffer, each for 10 min, and incubated with anti-IF 488 antibody (Servicebio, Cat
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