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No clinical safety or efficacy issues were identified

The resulting docking poses obtained from Autodock Vina applying our settings resembled almost perfectly the tyrosine pose found in the crystal structure of the Bm TYR-tyrosine complex (PDB entry 4P6R) 68 indicating that the defined settings were suitable

The systemic distribution means effects spread throughout the body rather than concentrating in any single area

Low TEER values are indicative of increased permeability to ions