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An increase in temperature within PDAC tumor tissue drives alterations in lipid metabolism, including a decrease in PUFAs such as phosphatidylcholine plasmalogen (PC-P), attenuating lipid peroxidation and ferroptosis, and further drives gemcitabine resistance in PDAC through the p38-MAPK pathway [154]

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SPECIAL CONCERNS ABOUT THE LONG-TERM DEFECTIVE QUALITY CONTROL OF ACETAMINOPHEN PRODUCTS All of the information to this point has been directed to the toxicity of pure acetaminophen