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This means that less is known about its potential impact on human health and this could be a factor for risk-averse researchers

Bitter receptor activation is an acute response that can occur within hours of ingestion

Kim B, Woo MJ, Park CS et al (2017) Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid-Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPAR/CPT-1 Pathway and in Acute Hyperlipidemia Mouse Model

This directly enhances nerve fiber excitability and exacerbates pain [50, 51]

Pain tracking Use a simple 0 to 10 numeric rating scale, recorded at the same time each day (morning and evening are ideal)