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68 vs 72 weeks STEP-1 (NEJM 2021) vs SURMOUNT-1 (NEJM 2022) head-to-head body weight loss

Larger needles cause more tissue displacement and tend to produce more discomfort

The combination therapy further induced significant positive changes in body mass index (BMI), blood pressure, total cholesterol, fasting plasmatic glucose low-density lipoprotein (LDL), and the albumin to creatinine ratio

This long-term approach prevents the metabolic adaptation that usually causes weight regain after traditional dieting

If systolic blood pressure falls below 90 mmHg or the patient becomes symptomatic, a prompt review of the antihypertensive regimen is warranted