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34 Each episode typically lasts from several days to four weeks and resolves spontaneously without specific treatment (Table 1)

Gene Activation: MC1R activation initiates a signaling cascade (cAMP production $\rightarrow$ MITF expression) that induces the enzymes (tyrosinase) necessary for eumelanin production

We believe that this is unlikely or, if any, makes only a small contribution because of the following reasons

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Transgenic plant aequorin reports the effects of cold shock and elicitors on cytoplasmic calcium