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Interestingly, omega-3 PUFAs were evaluated in rat models of intestinal damage by MTX, and this study demonstrated that omega-3 PUFAs exhibited the ability to prevent intestinal damage and stimulate intestinal recovery

Much of the current evidence is preclinical (cell and animal studies), and human data is still limited

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much of the data comes from manufacturer specifications or forums/communities

Since then, PPIs and other acid-suppressing medications have been shown in numerous studies to decrease calcium absorption [208, 212-214] with omeprazole causing a 41% decrease in one study [208] and long-term PPI usage has been increasingly associated with an increased occurrence of bone fractures