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Why the heart and liver benefit, even without direct targets Habegger says one of the most striking findings from large clinical trials is that GLP-1 drugs reduce the risk of heart attacks, strokes and cardiovascular death

363,364 Dietary modifications, such as adherence to a low-purine diet and avoidance of alcohol, particularly beer and spirits, sugar-sweetened beverages, heavy meals, and excessive intake of meat and seafood, have demonstrated efficacy in reducing uric acid levels by approximately 10-15%

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These trends highlight the need for targeted interventions and resource allocation in regions with a high burden of disease (2)