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In practice, the functional tests are more expensive, and laboratories dont have the budget to do a lot of these functional tests

doi: 10.2337/db09-055 279 CauchiSNeadKTChoquetHHorberFPotocznaNBalkauBet al

The relatively short washing period (20 min) between the two stimulations could explain this, as molecular sensors involved may have been saturated or desensitized by the first stimulation by the time of the second stimulation